Richard J Ablin

Metastasis of Prostate Cancer - Cancer Metastasis - Biology and Treatment Richard J Ablin 2007 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: List of Contributors -- Chapter 1. Introduction: Metastasis as a Therapeutic Target / Richard J. Ablin, Malcolm D. Mason -- Chapter 2. The Natural History of Prostate Cancer / David F. Penson, Peter C. Albertsen -- Chapter 3. The Search for Genes Which Influence Prostate Cancer Metastasis: A Moving Target? / Norman J. Maitland -- Chapter 4. Polyunsaturated Fatty Acids and Prostate Cancer Metastasis / Wen G. Jiang -- Chapter 5. Role of Prostaglandin Synthesis and Cyclooxygenase-2 in Prostate Cancer and Metastasis / Alaa F. Badawi -- Chapter 6. Cell Cycle Regulation / Ruchi M. Newman, Bruce R. Zetter -- Chapter 7. Epithelial-Mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity / Mary J. C. Hendrix, Jun Luo, Elisabeth A. Seftor, Navesh Sharma, Paul M. Heidger, Michael B. Cohen, Robert Bhatty, Jirapat Chungthapong, Richard E. B. Seftor, David Lubaroff -- Chapter 8. Orthotopic Metastatic Mouse Models of Prostate Cancer / Robert M. Hoffman -- Chapter 9. ?-Catenin, its Binding Partners and Signalling Mechanisms: Implications in Prostate Cancer / Gaynor Davies, Gregory M. Harrison, Malcolm D. Mason -- Chapter 10. Hepatocyte Growth Factor/Scatter Factor and Prostate Cancer Metastasis / Gaynor Davies, Wen G. Jiang, Malcolm D. Mason -- Chapter 11. Matrix Degradation in Prostate Cancer / Michael J. Wilson, Akhouri A. Sinha -- Chapter 12. The Biology of Bone Metastases from Prostate Cancer and the Role of Bisphosphonates / Noel W. Clarke, Herbert A. Fleisch -- Chapter 13. Hormone Therapy for Prostate Cancer / Mike Shelley, Charles Bennett, Derek Nathan, Oliver Sartor -- Chapter 14. Strategies for the Implementation of Chemotherapy and Radiotherapy / Paula Scullin, Joe M. O'Sullivan, Christopher C. Parker -- Chapter 15. Immuno-Gene Therapy for Metastatic Prostate Cancer / Takefumi Satoh, Terry L. Timme, Yehoshua Gdor, Brain J. Miles, Robert J. Amato, Dov Kadmon, Timothy C. Thompson -- Chapter 16. Distilling the Past - Envisioning the Future / Richard J. Ablin, Malcolm D. Mason -- Index. Publisher Marketing: Without metastasis, prostate cancer would be both tolerable and treatable. The high incidence of indolent and organ confined disease is testament to this sweeping generalisation. Equally, if molecular markers of metastatic spread can be identified, then the choice of treatment for many patients would be easier and more radical, even curative. However, should prevention and treatment of the primary tumors prove difficult or impossible, then a knowledge of the phenotype of advanced metastatic tumors should allow us to target these lesions for destruction by conventional (drug based) or more innovative means such as gene and/or immunotherapy (1). The process of metastasis has been reviewed many times (e. g., 2) and has been subdivided for ease of analysis into a number of discrete stages (see Figure 1). It has been suggested that at least 10 separate genetic 2. ECM degradation: migration MMP; Integrin; TIMP 3. Intravasation MMP TIMP 1. Cellular independence 4. Transport Adhesion loss and evasion (E Cadherin ) of host immune system MHCClass1 ICAM-1 to block T cell receptor 5. Arrest of movement: endothelial adhesion CD44 or switch 6. Extravasation to colonise new site 7. Proliferation at Laminin R distant site to form Integrin switch METASTASIS Figure 1. Stages in prostate cancer metastasis. Basic processes in tumor metastases are indicated in the boxes with some key changes in gene expression indicated at each stage by the solid arrows.