Yongwon Choi

Osteoimmunology: Interactions of the Immune and Skeletal Systems Yongwon Choi 2013 edition

Marc Notes: ; 8; This second edition of this book expands further on the first edition, which explored the relationship between the human immune system and the skeletal structure. In the past, scientists involved in immune and bone-cell investigations have rarely interacted in a significant way, as these disciplines have developed independently and, for the most part, remain separate. This book brings together ideas of international scientists from both fields in pursuit of new collaborations. This may facilitate greater understanding of the relationship between these fields.. Jacket Description/Back: This second edition of this book expands further on the first edition, which explored the relationship between the human immune system and the skeletal structure. In the past, scientists involved in immune and bone-cell investigations have rarely interacted in a significant way, as these disciplines have developed independently and, for the most part, remain separate. This book brings together ideas of international scientists from both fields in pursuit of new collaborations. This may facilitate greater understanding of the relationships between these fields."Table of Contents: Schnurri-3: A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF-?B Ligand.- The Negative Role of IDS in Osteoclastogenesis.- Functional Genetic and Genomic Analysis of Modeled Arthritis.- Dexamethsone Suppresses Bone Formation via the Osteoclast.- Immunologic Regulation of Bone Development.- PTH Regulates the Hematopoietic Stem Cell Niche in Bone.- Regulation of Hematopoietic Stem Cells in the Osteoblastic Niche.- The Chemokine CXCL12 and Regulation of Hsc and B Lymphocyte Development in the Bone Marrow Niche.- Osteoclast Precursor Cells.- Interaction with Estrogen Receptors as Treatment of Arthritis and Osteoporosis.- Novel Signaling Pathways and Therapeutic Targets in Osteoclasts.- The Enigmatic Function of TREM-2 in Osteoclastogenesis.- Role of Cell-matrix Interactions in Osteoclast Differentiation.- Positive and Negative Roles of IL-6, STAT3, and SOCS3 in Inflammatory Arthritis.- Control of Osteoclast Activity and Bone Loss by IKK Subunits: New Targets for Therapy.- Targeting Osteoporosis and Rheumatoid Arthritis by Active Vaccination Against RANKL.- RANKL Inhibition: From Mice to Men (and Women).