Roy Zent

Cell-Extracellular Matrix Interactions in Cancer Roy Zent 2010 edition

Marc Notes: Title from content provider.; Access is restricted to subscribing institutions. Jacket Description/Back: Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer. Table of Contents: 1. The Extracellular Matrix: An Overview / Jeffrey H. Miner -- 2. Integrin Structure and Function / Manakan Betsy Srichai, Roy Zent -- 3. Cancer in Context: Importance of the Tumor Microenvironment / Barbara Fingleton, Conor Lynch -- 4. Basement Membrane Collagens and Cancer / Vadim Pedchenko, Ambra Pozzi -- 5. Lammins and Cancer Progression / Jerome Jourquin, Manisha Tripathi, Cherise Guess, Vito Quaranta -- 6. Fibronectins and Their Receptors in Cancer / Christie J. Avraamides, Judith A. Varner -- 7. Vitronectin-Binding Integrins in Cancer / Eric Murphy, Dwayne Stupack -- 8. The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell-Extracellular Matrix Interaction / Rolf A. Brekken, Amy D. Bradshaw -- 9. Proteoglycans and Cancer / Ralph D. Sanderson, Yang Yang, Anurag Purushothaman, Yekaterma B. Khotskaya, Joseph P. Ritchie, Vishnu C. Ramani -- 10. Tetraspanins in Cancer / Andries Zijlstra -- 11. The Role of Integrin-Linked Kinase in Cancer Development and Progression / Paul C. McDonald, Shoukal Dedhar -- 12. Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer / Vita M. Golubovskaya, Elizabeth A. Beierle, Steven N. Hochwald, Elena V. Kurenova, William G. Cance -- Index. Publisher Marketing: Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.