Vladimir Berezin

Structure and Function of the Neural Cell Adhesion Molecule NCAM - Advances in Experimental Medicine and Biology Vladimir Berezin 2010 edition

Marc Notes: Includes bibliographical references and index. Jacket Description/Back: Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synaptic contacts associated with plasticity including learning and memory. More than eighty CAMs were found to be localized at synaptic sites, where they in a regulated manner bridge pre- and postsynaptic specializations thereby modulating synaptic function. Structure and Function of the Neural Cell Adhesion Molecule NCAM describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM). NCAM is one of the first identified and most studied CAMs, and this book is the first attempt to collectively summarize our current knowledge of this important cell adhesion molecule. Table of Contents: Part I. Structure and Ligands of NCAM -- Structural Biology of NCAM / Vladislav Soroka, Christina Kasper, Flemming M. Poulsen -- Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses / Janne Nielsen, Nikolaj Kulahin, Peter S. Walmod -- Intracelluar Ligands of NCAM / Bettina BUttner, RUdiger Horstkorte -- NCAM and the FGF-Receptor / Vladislav V. Kiselyov -- The Role of ATP in the Regulation of NCAM Function / Martin V. HUbschmann, Galina Skladchikova -- Part II. NCAM and Polysialic Acid -- Polysialylation of NCAM / Herbert Hildebrandt, Martina MUhlenhoff, Rita Gerardy-Schahn -- Structural Basis for the Polysialylation of the Neural Cell Adhesion Molecule / Karen J. Colley -- The Role of PSA-NCAM in Adult Neurogenesis / Eduardo Gascon, Laszlo Vutskits, Jozsef Zoltan Kiss -- Use of PSA-NCAM in Repair of the Central Nervous System / Abderrahman El Maarouf, Urs Rutishauser -- Part III. NCAM-Mediated Signal Transduction -- Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth / Dorte Kornerup Ditlevsen, Kateryna Kolkova -- Role of the Growth-Associated Protein GAP-43 in NCAM-Mediated Neurite Outgrowth / Irina Korshunova, Mark Mosevitsky -- The Neural Cell Adhesion Molecule NCAM and Lipid Rafts / Gro Klitgaard Povlsen, Dorte Kornerup Ditlevsen -- The Neural Cell Adhesion Molecule and Epidermal Growth Factor Receptor: Signaling Crosstalk / Gro Klitgaard Povlsen -- Part IV. NCAM Metabolism -- Biosynthesis of NCAM / Kateryna Kolkova -- Soluble NCAM / Thomas Secher -- Part V. NCAM, Synapses, Emotions, and Memory -- Role of NCAM in Spine Dynamics and Synaptogenesis / D. Muller, P. Mendez, M. DeRoo, P. Klauser, S. Steen, L. Poglia -- NCAM in Long-Term Potentiation and Learning / Barbara P. Hartz, Lars Christian B. ROnn -- Role of NCAM in Emotion and Learning / Lisa Conboy, Reto Bisaz, Kamila Markram, Carmen Sandi -- Part VI. NCAM in Disease -- NCAM in Neuropsychiatric and Neurodegenerative Disorders / Leann H. Brennaman, Patricia F. Maness -- Neural Cell Adhesion Molecule in Cancer: Expression and Mechanisms / Silvia Zecchini, Ugo Cavallaro -- Part VII. Pharmacology of NCAM: NCAM Mimetics -- NCAM Mimetic Peptides: An Update / Vladimir Berezin, Elisabeth Bock -- Synthetic NCAM-Derived Ligands of the Fibroblast Growth Factor Receptor / Stine Maria Hansen, Shizhong Li, Elisabeth Bock, Vladimir Berezin -- Dendritic Spine and Synapse Morphological Alterations Induced by a Neural Cell Adhesion Molecule Mimetic / Michael Stewart, Victor Popov, Nikolai Medvedev, Paul Gabbott, Nicola Corbett, Igor Kraev, Heather Davies -- Part VIII. Orthologs and Paralogs of NCAM -- Fasciclin II: The NCAM Ortholog in Drosophila melanogaster / Lars V. Kristiansen, Michael Hortsch -- The Neural Cell Adhesion Molecule NCAM2/OCAM/RNCAM, a Close Relative to NCAM / Nikolaj Kulahin, Peter S. Walmod -- Part IX. Conclusion -- Honoring Dr. Elisabeth Bock / Vladimir Berezin -- Index. Publisher Marketing: Based on published data and on our own experimental findings, we analyze key aspects of the structure and functions of the neural cell adhesion molecule (NCAM). We conclude that identification of NCAM mimetics opens up novel prospects for elucidation of the role of NCAM in neural differentiation and plasticity and, therefore, for practical development of new tools useful for the treatment of neurodegenerative disorders.