Peter Ten Dijke

Smad Signal Transduction: Smads in Proliferation, Differentiation and Disease - Proteins and Cell Regulation Peter Ten Dijke 2006 edition

Marc Notes: Includes bibliographical references and index. Review Quotes: From the reviews: "This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. a ] This is definitely an a ~all-ina (TM) book for those interested in or working on TGFA receptor signal transduction in general and Smad proteins in particular. a ] it is a must for all of us working in the field of TGFA signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007) Review Quotes: From the reviews: "This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. This is definitely an all-in book for those interested in or working on TGFss receptor signal transduction in general and Smad proteins in particular. it is a must for all of us working in the field of TGFss signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007)"Table of Contents: Contributors -- Preface: The Smad Family / Peter ten Dijke, Carl-Henrik Heldin -- 1. Molecular Evolution of Smad Proteins / Stuart J. Newfeld, Robert G. Wisotzkey -- 2. C. elegans TGF- Signaling Pathways / Richard W. Padgett, Garth I. Patterson -- 3. Smads in Drosophila - Interpretation of Graded Signals in vivo / Laurel A. Raftery, Svetlana Korochkina, Jing Cao -- 4. Delineating the TGF-/Smad-induced Cytostatic Response / Fang Liu -- 5. Smads in Mesenchymal Differentiation / Rik Derynck, Lisa Choy, Tamara Alliston -- 6. Smad Proteins in Apoptotic and Survival Signaling / Andrew R. Conery, Kunxin Luo -- 7. TGF-/Smad Signaling in Epithelial to Mesenchymal Transition / Aristidis Moustakas, Marcin Kowanetz, Sylvie Thuault -- 8. Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Development, Disease, and Cancer / Michael Weinstein, Chu-Xia Deng -- 9. Trafficking of Serine/Threonine Kinase Receptors and Smad Activation / Christine Le Roy, Rohit Bose, Jeffrey L. Wrana -- 10. Nucleocytoplasmic Shuttling of Smad Proteins / Bernhard Schmierer, Caroline S. Hill -- 11. Structural Insights into Smad Function and Specificity / Yigong Shi -- 12. Regulation of Smad Function by Phosphorylation / Ihor Yakymovych, Serhiy Souchelnytskyi -- 13. Regulation of Smad Functions through Ubiquitination and Sumoylation Pathways / Xin-Hua Feng, Xia Lin -- 14. Smad Transcriptional Co-activators and Co-repressors / Kohei Miyazono, Shingo Maeda, Takeshi Imamura -- 15. Integration of Signaling Pathways via Smad Proteins / Etienne Labbe, Liliana Attisano -- 16. Interplay between Smad and Map Kinase Signaling Pathways / Delphine Javelaud, Alain Mauviel -- 17. Gene Expression Signatures of TGF-/Smad-Induced Responses / Erwin P. Bottinger, Wenjun Ju -- 18. Systems Biology Approaches to TGF-/Smad Signaling / Muneesh Tewari, Arvind Rao -- 19. Inhibitory Smads: Mechanisms of Action and Roles in Human Diseases / Atsuhito Nakao -- 20. Alterations in Smad Signaling in Carcinogenesis / Seong-Jin Kim, John J. Letterio -- 21. TGF- Receptor Kinase Inhibitors for the Treatment of Cancer / Michael Lahn, Brandi Berry, Susanne Kloeker, Jonathan M. Yingling -- 22. TGF- Receptor Kinase Inhibitors for Treatment of Fibrosis / Nicholas J. Laping, Stephane Huet -- Name Index. Review Quotes: From the reviews: "This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. This is definitely an all-in book for those interested in or working on TGF receptor signal transduction in general and Smad proteins in particular. it is a must for all of us working in the field of TGF signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 2007) Review Quotes: From the reviews: "This text would ideally gather all relevant information on Smads in signal transduction in general and at the crossroads between developmental and cell biology in particular. This is definitely an all-in book for those interested in or working on TGFss receptor signal transduction in general and Smad proteins in particular. it is a must for all of us working in the field of TGFss signaling and Smad signal transduction, and for those of us who are teaching post-graduate courses in signal transduction." (Danny Huylebroeck, Development, Vol. 134 (24), 200Publisher Marketing: For the first time, world-leading experts in the area of cellular signaling have joined to the production of a book on Smad signal transduction. Smads are the principal intracellular effectors of TGF-b family members that control numerous cellular responses with critical roles in development and in tissue homeostasis. In a series of 22 cutting-edge chapters, forward looking reviews of Smads are provided that cover their discovery, evolution, role in development, mechanism of action and regulation, and how deregulation in Smad signalling contributes to human diseases. Written for an audience with basic understanding of molecular and cell biology, this volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.