D Haussinger

Hepatic Encephalopathy and Nitrogen Metabolism D Haussinger 2006 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: List of contributors -- Preface -- Foundation of the 'International Society on Hepatic Encephalopathy and Nitrogen Metabolism' (ISHEN) D H&aumlet;ussinger -- Section I. Physiology and pathophysiology of astrocytes -- 1. Water transport in the brain: basic concepts and astrocytic swelling / HK Kimelberg -- 2. Osmotic and oxidative stress in hepatic encephalopathy / F Schliess, B G&oumlet;rg, HJ Bidmon, D H&aumlet;ussinger -- 3. NADPH oxidase is a major source of swelling-induced generation of reactive oxygen species in rat astrocytes / R Reinehr, B G&oumlet;rg, HJ Bidmon, D H&aumlet;ussinger -- 4. Detoxification of hydrogen peroxide by astrocytes / R Dringen, JR Liddell, T Knorpp, SR Robinson -- 5. Glutamate release from astrocytes: impact on neuronal function / EB Malarkey, V Parpura -- 6. Hepatic stellate cells and astrocytes: similarities and differences / A Geerts, M Pekny -- 7. Localization and function of the ATP-binding cassette C (ABCC/MRP) efflux pumps in human brain / AT Nies, M Rius, J K&oumlet;nig, C Herold-Mende, D Keppler -- 8. Glial mechanisms of axonal growth protection from ammonia / O Braissant, H Henry, L Cagnon, P Honegger, C Bachmann -- 9. Selenoprotein P: a link between liver and brain / H Steinbrenner, L Alili, H Sies, P Brenneisen -- Section II. Pathogenesis of hepatic encephalopathy -- 10. The peripheral benzodiazepine receptor and neurosteroids in the pathogenesis of hepatic encephalopathy and ammonia neurotoxicity / MD Norenberg, AR Jayakumar, KV Rama Rao, KS Panickar -- 11. Glutamatergic synaptic regulation deficit in liver failure: a review of molecular mechanisms / H Chan, RF Butterworth -- 12. Synaptic plasticity in animal models relevant for hepatic encephalopathy / OA Sergeeva, AN Chepkova, N Doreulee, O Selbach, HL Haas -- 13. N-methyl-D-aspartate receptors in hyperammonaemia and hepatic encephalopathy / S Erceg, R Rodrigo, P Monfort, M Llansola, C Montoliu, AM Sanchez-Perez, O Cauli, B Piedrafita, V Felipo -- 14. Prehepatic portal hypertension and mitochondrial dysfunction in brain hippocampus / JC Perazzo, S Lores Arnaiz, MA Fernandez, N Lago, A Lemberg -- 15. Nuclear magnetic resonance studies in experimental animal models of hepatic encephalopathy / C Zwingmann -- 16. The role of inflammation in hepatic encephalopathy / GAK Wright, DA Shawcross, NA Davies, R Jalan -- Section III. Brain imaging in hepatic encephalopathy research -- 17. Altered neural oscillations and synchronization: a pathophysiological hallmark of hepatic encephalopathy / A Schnitzler, M Butz, J Gross, G Kircheis, D H&aumlet;ussinger, L Timmermann -- 18. Neurotransmitter receptor alterations in hepatic encephalopathy / N Palomero-Gallagher, G Reifenberger, G Kostopoulos, G Kircheis, D H&aumlet;ussinger, K Zilles -- 19. Quantitative T1 and water content mapping in hepatic encephalopathy / NJ Shah, H Neeb, G Kircheis, D H&aumlet;ussinger, K Zilles -- 20. Central nervous system involvement in hepatitis C virus infection: what to measure? / DM Forton, J Allsop, HC Thomas, SD Taylor-Robinson -- 21. Localized magnetic resonance-correlated spectroscopy using two spectral dimensions: theoretical description and pilot investigation in hepatic encephalopathy / A Huda, N Binesh, S Han, MA Thomas -- Section IV. New aspects of nitrogen metabolism -- 22. Urea cycle disorders / C Bachmann, O Braissant, L Cagnon, H Henry, I Kern -- 23. Pathophysiology of citrin deficiency / T Saheki, K Kobayashi, M lijima, MX Li, M Horiuchi, A Tabata, YB Lu, M Ushikai, M Terashi, M Moriyama -- 24. Hepatic encephalopathy in organic acidurias: hyperammonaemia and energy failure / S K&oumlet;lker, MA Schwab, F H&oumlet;rster, JG Okun -- 25. Glutamine synthetase deficiency in the human / J H&aumlet;berle, B G&oumlet;rg, A Toutain, F Schliess, D H&aumlet;ussinger -- 26. Hepatic dysfunction and encephalopathy in inborn errors of metabolism / BC Schwahn -- 27. Amino acids and mammalian target of rapamycin-dependent signalling / AJ Meijer, PF Dubbelhuis, JHPM Houben-Weerts -- 28. Ceramide is a negative regulator of insulin action, nutrient uptake and protein synthesis in cultured rat skeletal muscle cells / HS Hundal, R Hyde, D Powell, E Hajduch, N Dimopoulos, S Turban, PM Taylor -- 29. Ammonia transport in aquaporins: molecular mechanisms and clinical relevance / LM Holm, T Zeuthen -- 30. Glutamine synthetase as a target of ?-catenin: new insights into hepatic heterogeneity / R Gebhardt, E Ueberham, F Gaunitz -- 31. Ammonia metabolism in liver cirrhosis / M S&ophi;rensen, S Keiding -- Section V. Clinical assessment of hepatic encephalopathy -- 32. Definition and assessment of low-grade hepatic encephalopathy / D H&aumlet;ussinger, J Cordoba, G Kircheis, H Vilstrup, WE Fleig, EA Jones, F Schliess, AT Blei -- 33. Hepatic encephalopathy in acute liver failure / AT Blei -- 34. Quality of life in chronic liver diseases and in hepatic encephalopathy / J Cordoba -- 35. Hyponatraemia: a risk factor of hepatic encephalopathy in cirrhosis / M Guevara, P Gines -- 36. Neuropsychological dysfunction in minimal hepatic encephalopathy: a review compared with own experience / D Mapelli, P lannizzi, A Biancardi, S Schiff, F Del Piccolo, P Valenti, P Amodio -- 37. Computerized or paper-and-pencil psychometric tests for the assessment of hepatic encephalopathy? / H Mardini, BK Saxby, C Record -- 38. Neurophysiological basis of critical flicker frequency (CFF) analysis / G Kircheis, O Zafiris, K Zilles, D H&aumlet;ussinger -- 39. Critical assessment of the PHES test battery in patients with low-grade hepatic encephalopathy / G Kircheis, R G&oumlet;rtelmeyer, WE Fleig, D H&aumlet;ussinger -- Section VI. Treatment -- 40. Evidence-based medicine and hepatic encephalopathy treatment / KD Mullen -- 41. Brain oedema in acute liver failure: mechanisms and therapeutic options / HR Pedersen, F Stolze Larsen -- 42. Hepatic encephalopathy and artificial liver support systems / RAFM Chamuleau, PPC Poyck -- 43. Prometheus(R) - a new extracorporeal system for the treatment of liver failure / K Rifai -- 44. Modulation of Intestinal flora for the treatment of hepatic encephalopathy in cirrhosis / S Galhenage, J Almeida, J Yu, J Kurtovic, I Segal, SM Riordan -- 45. Prevention of hepatic encephalopathy after portosystemic shunt F Nicolao / S Angeloni, M Merli, L Ridola, O Riggio -- 46. Milestones in hepatic encephalopathy research / EA Jones -- Group Picture -- Index. Publisher Marketing: The most recent developments in research on hepatic encephalopathy, inborn hyperammonaemic syndromes and nitrogen metabolism, including clinical aspects, were presented by international acknowledged experts in this active research field at the 12th International Symposium on Hepatic Encephalopathy, which was held from June 1 to 4, 2005 in Solingen, Schloss Burg, Germany. This book comprehensively summarizes the most important novel issues on hepatic encephalopathy and nitrogen metabolism and is of interest not only for scientists in the field, but also for interested clinicians. This update of present knowledge will provide a platform for future research in the field of hepatic encephalopathy and nitrogen metabolism.