George J Klir

Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis - Molecular Biology Intelligence Unit George J Klir 2003 edition

Marc Notes: Bibl. ref. & index.; Based on pre-pub. info. only. Publisher Marketing: Complex molecular mechanisms involving microbiology and immunology define the host-pathogen relationship. These mechanisms can be the basis for new drugs and vaccine design. This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Chapters are grouped into five sections: I. Endocytosis and phagocytosis. Collectively, the chapters of this section review basic knowledge regarding intracellular organelles are involved in membrane interactions with pathogen-containing vacuoles. II. Professional and non-professional phagocytes. Here the authors describe the major differences between the two host cell types, which can be infected by microorganisms. III. Maturation pathways of bacteria-containing vacuoles. Molecular interactions between vacuoles and intracellular organelles leading to the search of the Holy Grail, the replication niche, are described. IV. Host response. Host cells are able to react against intruders and eventually mount host responses. In these chapters the various types of host response mechanisms against intracellular intruders are reviewed. V. knowledge of bacteria-host cell interactions will be acquired fast enough to find the necessary tools for controlling microorganism development. This comprehensive book should appeal to scientists interested in cell biology, microbiology and immunology, as well as to clinically-oriented investigators concerned with infectious diseases.

Contributor Bio:  Klir, George J GEORGE J. KLIR, PhD, is currently Distinguished Professor of Systems Science at Binghamton University, SUNY. Since immigrating to the U. S. in 1966, he has held positions at UCLA, Fairleigh Dickinson University, and Binghamton University. He is a Life Fellow of IEEE, IFSA, and the Netherlands Institute for Advanced Studies. He has served as president of SGSR, IFSR, NAFIPS, and IFSA. He has published over 300 research papers and sixteen books, and has edited ten books. He has also served as Editor in Chief of the International Journal of General Systems since 1974 and of the IFSR International Book Series on Systems Science and Engineering since 1985. He has received numerous professional awards, including five honorary doctoral degrees, Bernard Bolzano's Gold Medal, Arnold Kaufmann's Gold Medal, and the SUNY Chancellor's Award for "Exemplary Contributions to Research and Scholarship." He is listed in Who's Who in America and Who's Who in the World. His current research interests include intelligent systems, soft computing, generalized information theory, systems modeling and design, fuzzy systems, and the theory of generalized measures. He has guided twenty-nine successful doctoral dissertations in these areas. Some of his research has been funded by grants from NSF, ONR, the United States Air Force, NASA, Sandia Labs, NATO, and various industries.