Nancy Khadori

Biomedical Aspects of Histamine: Current Perspectives Nancy Khadori

Marc Notes: Includes bibliographical references and index.; Based on publisher-provided data. Jacket Description/Back: Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology. Table of Contents: Part I. Histamine Biology and Physiology -- 1. An Overview of Histamine Synthesis, Regulation and Metabolism, and its Clinical Aspects in Biological System / Mohammed Shahid, Trivendra Tripathi, Nancy Khardori, Rahat Ali Khan -- 2. Regulation of Mammalian Histamine Synthesis: Histidine Decarboxylase / Satoshi Tanaka, Atsushi Ichikawa -- Part II. Enzymology in Histamine Biology -- 3. Enzymology in Histamine Biogenesis / Almudena Pino-Angeles, Aurelio A. Moya-GarcIa, Miguel Angel Medina, Francisca SAnchez-JimEnez -- Part III. Pharmacology of Histamine Noble Receptors and Their Ligands in Drug Development -- 4. Biological and Pharmacological Aspects of Histamine Receptors and Their Ligands / Mohammed Shahid, Trivendra Tripathi, Rahat Ali Khan, Nancy Khardori, Ali Ibrahim Al-Sultan, Hamdan Ibrahim AL-Mohammed, Abdulrahman A. Alsultan, Anwar Huq, Aijaz Ahmed Khan, Mashiatullah Siddiqui -- Part IV. Histamine Role in Immune Modulation and Regulation -- 5. The Role of Histamine in Immunoregulation in Context of T-Regulatory and Invariant NKT Cells / Varun Dwivedi, Renukaradhya J. Gourapura -- 6. Immune Regulation by Various Facets of Histamine in Immunomodulation and Allergic Disorders / Trivendra Tripathi, Mohammed Shahid, Farrukh Sobia, Anuradha Singh, Haris M. Khan, Rahat Ali Khan, Mashiatullah Siddiqui -- Part V. Histamine in Regulation of Cell Proliferation and Differentiation -- 7. Effects of Histamine on Lymphocytes / Manzoor M. Khan -- 8. Histamine Aspects in Acid Peptic Diseases and Cell Proliferation / Jameel Ahmad, Monika Misra, Waseem Rizvi, Anil Kumar -- Part VI. Histamine Role in Pathogenesis and Diagnosis of Allergic, Inflammatory, Autoimmune and Cancer Diseases -- 9. Histamine: Role in Pathogenesis of Autoimmune, Allergic, Inflammatory and Malignant Diseases / Trivendra Tripathi, Mohammed Shahid, Haris M. Khan, Mashiatullah Siddiqui, Aijaz Ahmed Khan, Rahat Ali Khan -- 10. Biological Characteristics of Histamine Receptors in Airways Disease Management / Rajni Kant Shukla, Priyanka Jain, Sandeep Bhattacharya -- Part VII. Histamine Role in Inflammation and Allergy -- 11. Mast Cells as a Source and Target for Histamine / Ewa Brzezinska-Blaszczyk -- 12. Histamine H1 Receptor Gene Expression Mechanism as a Novel Therapeutic Target of Allergy / Hiroyuki Fukui, Hiroyuki Mizuguchi -- Part VIII. Histamine in the Nervous System -- 13. The Neuronal Histamine and it's Receptors as New Therapeutic Targets for Food Intake and Obesity / Takayuki Masaki -- 14. Implications of Histaminergic System in Brain Histamine Dysfunction / Aijaz Ahmed Khan, Trivendra Tripathi, Mohammed Shahid, Haris M. Khan, Rahat Ali Khan -- Part IX. Histamine H3 Receptor: A Target for Momentous Brain Research -- 15. Pre-Synaptic Control by Histamine H3 Receptors of Neurotransmitter Release / AngElica Osorio-Espinoza, Judith Ramos-JimEnez, JosE-Antonio Arias-MontaNo -- Part X. Histamine H4 Receptor: A Noble Target for Inflammatory and Immune Research -- 16. Expression of Histamine H4 Receptor in Human Synovial Cells and Dermal Tissues / Yoshiko Matsuda, Katsunori Yamaura, Masahiko Suzuki, Takao Namiki, Koichi Ueno -- Part XI. Role of Histamine in Reproductive Function -- 17. Novel Role for Histamine Through Classical H1 and H2 Receptors: Regulation of Leydig Cell Steroidogenesis and its Implications for Male Reproductive Function / Carolina Mondillo, Omar Pedro Pignataro -- 18. Possible Effect of Histamine in Physiology of Female Reproductive Function: An Updated Review / Nasreen Noor, Trivendra Tripathi, Shagufta Moin, Abdul Faiz Faizy -- Part XII. Other Biomedical Aspects of Histamine Agonists, Antagonists, and Inverse Agonists -- 19. Histamine Role in Malaria / Adil Raza, Haris M. Khan, Fatima Shujatullah -- 20. Histamine-Cytokine and Histamine-Antibody Network in Immune Regulation / Trivendra Tripathi, Richa Pandey, Adil Raza, Mohammed Shahid, Haris M. Khan, Mashiatullah Siddiqui, Rahat Ali Khan -- Subject Index. Publisher Marketing: Since its identification by Sir Henry Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacologic effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their agnonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.

Contributor Bio:  Khardori, Nancy Nancy Misri Khardori born in Kashmir, India, in 1949, gained her MD in Microbiology and Immunology from the All India Institute of Medical Sciences, New Delhi, India, in 1977. She was a post-doctoral fellow at Southern Illinois University School of Medicine, becoming a fellow in infectious diseases at the University of Texas, and then Assistant Professor of Microbiology and Immunology in 1986. She has been Professor of Medicine and Professor of Microbiology and Immunology at Southern Illinois University School of Medicine since 1995, where she also holds several posts as Medical Director. Professor Khardori works in the American Society of Tropical Medicine and Hygiene, the American Heart Association, Illinois State Medical Society, and the Illinois Department of Public Health. Nancy Khardori is a fellow of both the American College of Physicians and the Infectious Diseases Society of America, and is a member of numerous societies, including the American Society for Microbiology, the American Society for Internal Medicine, American Medical Association, New York Academy of Sciences and the International Society for Infectious Diseases. She is a reviewer for six journals and consults on new drug development for two companies. Her research currently focuses on the diagnosis and management of infectious diseases, infections in immunocompromised patients, viral hepatitis and sexually transmitted diseases.