Anthony Serracino-inglott

Chronopharmacology in Hypertension: the Case for Perindopril and Valsartan Anthony Serracino-inglott

Chronotherapy is a new option to optimize blood pressure (BP) control, allowing individual treatment of hypertension according to the circadian BP profile of each patient. The objectives of this study were to test anti hypertensive drugs, perindopril and valsartan for their effect on 24h BP profile and to compare the effects of morning vs evening dosing on circadian BP. Recruited patients had their 24h BP profiles measured using an ambulatory blood pressure monitor (ABPM) to evaluate the effects of morning vs. evening dosing of perindopril and valsartan on circadian blood pressure. Patients suffering from hypertension but taking no medications and normotensive patients were recruited as controls.