Aleksandr Vital'evich Polevshchikov

Analiz Mekhanizmov Kletochnykh Reaktsiy Vrozhdyennogo Immuniteta Iglokozhikh: Sravnitel'no-evolyutsionnyy Analiz Aleksandr Vital'evich Polevshchikov Russian edition

Monografiya posvyashchena aktual'noy probleme immunologii ? izucheniyu protsessa stanovleniya immunnoy sistemy, evolyutsii funktsiy vrozhdennogo i priobretennogo immuniteta na primere zashchitnykh reaktsiy iglokozhikh. Polucheny novye svedeniya o mekhanizmakh kletochnykh reaktsiy vrozhdennogo immuniteta iglokozhikh zhivotnykh i sposobakh ikh regulyatsii na rannikh stadiyakh stanovleniya immunnoy sistemy. Dokazana analogichnost' mekhanizmov regulyatsii kletochnykh reaktsiy vrozhdennogo immuniteta u iglokozhikh i pozvonochnykh zhivotnykh. Pokazana regulyatsiya funktsional'noy aktivnosti tsirkuliruyushchikh kletok v allogennykh i tsitotoksicheskikh reaktsiyakh tsitokinopodobnymi faktorami, imeyushchimi skhodstvo s molekulami klyuchevykh semeystv tsitokinov cheloveka. Provedena morfologicheskaya kharakteristika etogo protsessa. Nakoplennyy material sushchestvenno dopolnyaet dannye o rannikh etapakh evolyutsii immunnoy sistemy i mozhet byt' ispol'zovan v pedagogicheskom protsesse v ramkakh lektsionnykh kursov po obshchey i sravnitel'noy immunologii. Razrabotannyy metod otsenki kletochnoy tsitotoksichnosti mozhet byt' ispol'zovan dlya izucheniya zashchitnykh reaktsiy bespozvonochnykh zhivotnykh razlichnykh taksonov v laboratoriyakh, vedushchikh issledovaniya po skhodnoy tematike.