M. Ashraf

Molecular Aspects of Breast Cancer: Brca Protein Expression and Its Correlation with Treatment of Sporadic Breast Cancer M. Ashraf

This monograph has dealt comprehensively with the genetic and molecular aspects of breast cancer. Introductory chapter highlights certain aspects like epidemiology and demographic trends in various regions of the world. The mechanism of involvement of different genes in the etiological process is discussed. Present day literature dealing with this subject has been reviewed and the referrences are provided at the end of the book. The book lays main focus on BRCA protein expression and its derangement in sporadic breast cancer and whether this premise can be utilized in improving on the treatment regimen selection for the patients. This provides a new insight into the subject in the sense that so far this aspect has not been thoroughly studied. The treatment regimen selection has hitherto been dictated by hormonal receptor and Her2/neu receptor analysis. A new hypothetical model of managing breast cancer in sporadic setting has been provided in the present book based on the expression of BRCA protein rather than on the basis of mutational analysis.