Selim F. Estefan

Alternative Opportunities for Alzheimer's Disease: Hormones Away from Alzheimer's Disease Selim F. Estefan

Alzheimer's disease is a progressive disorder in which brain cells deteriorate, resulting in the loss of cognitive functions, primary memory, judgment, reasoning, movement coordination, and pattern recognition. The goal of the present study is to evaluate the possible therapeutic role of hormones; estrogen, melatonin or DHEA in alleviating the neurological damage characterizing Alzheimer's disease in experimental animal model. The present study demonstrated that the treatment with either one of the selected hormones significantly ameliorated the neurodegeneration characteristic of Alzheimer's disease. These effects of the selected hormones were achieved through their powerful antioxidant, antiapoptotic, neurotrophic as well as antiamyloidogenic activities.