Rajesh Sharma

Estimation and Validation Methods for Drotaverine and Nimesulide: a Spectrophotometric Technology Rajesh Sharma

Most of the pharmaceutical industries, are manufacturing multiple drug formulation to meet the market demand. This drug combination has more advantages and efficiency as compared single drug components. Quantitative analysis of multicomponent formulations usually requires a prior extraction of drugs from the excipients or elaborate separation procedure for multiple drug themselves, hence making them tedious and time consuming. There is likely to be loss of accuracy and precision due to extraction and separation. The simultaneous analysis procedures avoid these time consuming extraction and separation, and are economical in the sense that use of expensive reagents is minimized. As a result, a simple, rapid and economical method for the simultaneous analysis of multicomponent formulations, which do not require extraction or separation of the analyte from themselves or from the excipients, becomes necessary for the pharmaceutical industry. Therefore, in the proposed project, a successful attempt has been made to develop simple, precise and accurate methods for the simultaneous analysis of Drotaverine Hydrochloride and Nimesulide in a two component tablet formulation.