Klaus Pfeffer

Function and Specificity of / T Cells: International Workshop, Schloss Elmau, Bavaria, FRG October 14-16, 1990 - Current Topics in Microbiology and Immunology Klaus Pfeffer Softcover reprint of the original 1st ed. 1991 edition

Description for Sales People: The current rersearch in y/ T cells presented here exemplifies that our knowledge of this cell population in the immune system is steadily increasing. To convert today's vision on function and specificity of y/ T cells into accepted conclusions, additional effort, scientific exchange and cooperative studies carried out with a wide spectrum of techniques are required. Table of Contents: Genomic Organization.- Genetic Organization of Human T Cell Receptor Gamma Locus..- Differentiation In Vitro.- Development of Human T Cells Expressing TCR In Vitro.- From the Development Expression of T Cell Receptors to the Implications in the Aquisition of Tolerance.- Culture Conditions Dictate Whether Mouse Fetal Thymus Lobes Generate Predominantly ?/? or ?/? T Cells.- Preferential Development of ?/?-Bearing T Cells in Athymic Nude Bone Marrow.- Developmentally Ordered Expression of TCR V?7 Subfamily Genes.- Maturation/ Selection.- Tissue Distribution and Repertoire Selection of Human T Cells: Comparison With the Murine System.- Evidence For Controlled Gene Rearrangements and Cytokine Production During Development of Human TCR + Lymphocytes.- Thymic and Extrathymic Development of Human ?/? T Cells.- Differential Effects of Anti-CD3 Antibodies In Vivo and In Vitro on and T Cell Differentiation.- The Beginning and the End of the Development of TCR Cells in the Thymus.- Cyclosporin A (CsA) Prevents the Generation of Mature Thymic ?/? T Cells but Spares ?/? T Lymphocytes..- Other Species.- Lack of Alloantigen-Specific Cytotoxic T Cell Activity in the TCR T Cell Subpopulation of Alloantigen-Immune Chickens.- Thymic Nurse Cells: A Site for Positive Selection and Differentiation of T Cells.- Marked Variations in T Cell Numbers and Distribution Throughout the Life of Shepp.- ?/? T-Lymphocyte Subsets in Swine.- Transgenic Mice/Manipulation In Vivo.- Mechanisms of Development of T Cell Antigen Receptor-Bearing Cells in T Cell Antigen Receptor Transgenic Mice.- Ligand Specificity and Repertoire Development of Murine TCR Cells.- Antigen/ Heat Shock Proteins.- Specificity of Mycobacteria/Self-Reactive Cells.- Modulation of Murine Self Antigens by Mycobacterial Components..- In Vitro Activation of Human ?/? T Cells by Bacteria: Evidence for Specific Interleukin Secretion and Target Cell Lysis..- A Dichotomy Between the Cytolytic Activity and Antigen-Induced Proliferative Response of Human T Cells.- Analysis of Primary T Cell Responses to Intact and Fractionated Microbial Pathogens..- function and Specificity of Human V?9/V?2 T Lymphocytes.- Daudi Cell Specificity Correlates With the Use of aV?9-V?2 Encoded TCR .- TCT.1: ATarget Structure for a Subpopulation of Human ?/? T Lymphocytes..- Activation and Deactivation of Cloned ?/? T Cells.- T Cells in Leprosy Lesions.- Modifications of T Lymphocytes in the Rheumatoid Arthritis Joint.- Phenotypic and Functional Heterogeneity of Double Negative (CD4-CD8-) TcR+T Cell Clones.- Restriction.- Specificity of Human T Lymphocytes Expressing a ?/? T Cell Antigen Receptor. Recognition of a Polymorphic Determinant of HLA Class I Molecules by a ?/? Clone.- Antigens and Antigen-Presenting Molecules for T Cells.- Correlation Between TCRV Gene Usage and Antigen Specificities in Human T Cells.- Qa-1 Restricted T Cells Can Help B Cells..- CD5 B Cells.- CD5 B Cells in the Mouse.- Mucosal and Dermal Immunity.- Selection ofV?4+T Cell Receptors of Intestinal Intraepithelial Lymphocytes is Dependent on Class II Histocompatibility Antigen Expression..- The Role of Fetal Epithelial Tissues in the Maturation/Differentiation of Bone Marrow-Derived Precursors into Dendritic Epidermal T Cells (DETC) of the Mouse.- Phenotypic and Functional Characterization of Human TCR + Intestinal Intraepithelial Lymphocytes..- A Search for Cells Carrying the ?/? T Cell Receptor in Mice Infected with Leishamia major.- Involvement of T Cells in Respiratory Virus Infections..