Franz Hefti

Growth Factors and Alzheimer's Disease - Research and Perspectives in Alzheimer's Disease Franz Hefti Softcover reprint of the original 1st ed. 1991 edition

Description for Sales People: The book provides stimulating hypotheses about the possible role of growth factors in the generation of senile plaques, the process of degeneration and regeneration in Alzheimer's disease, the expression of the gene of NGF and the possible use of NGF in treatment. Table of Contents: Neurotrophic Factors and Neurodegenerative Diseases.- Survival, Regrowth, and Reconnection of Injured Retinal Ganglion Cells.- Localizing Expression of the Three Members of the Nerve Growth Factor Family to Neurons in the Brain.- Nerve Growth Factor: Studies Addressing its Expression and Actions in the Central Nervous System.- Nerve Growth Factor Gene Expression in Actively Growing Brain Glia.- Human Nerve Growth Factor Receptor Expression in the CNS of Transgenic Mice.- Involvement of Protein Kinase C in the Regulation of Nerve Growth Factor Synthesis: A Possible Cause of Impaired Trophic Supply in Alzheimer s Disease?.- Distribution and Characterization of ?-Nerve Growth Factor Receptors in Alzheimer s Disease.- Regulation of Nerve Growth Factor Synthesis in the Central Nervous System by Cytokines and Implications for the Treatment of Alzheimer s Disease.- Nerve Growth Factor Expression and Function in the CNS.- Nerve Growth Factor and Behavioral Recovery After Brain Damage in Rats.- Functional Impairments that Develop in Nerve Growth Factor-Sensitive Neuronal Projections in the PNS and CNS of Aged Rats Are Ameliorated by Dietary Interventions.- Morphological and Behavioral Effects of Basic Fibroblast Growth Factor and Heparin on Transplanted Fetal Dopaminergic Neurons and Astrocytes in the Denervated Rat Caudate-Putamen.- Acidic Fibroblast Growth Factor Localization and Basic Fibroblast Growth Factor Binding Sites in the Eye and Optic Nerve.- Synthetic Peptide Agonists and Antagonists of Basic Fibroblast Growth Factor: Increasing Cellular Specificity of a Multifunctional Growth Factor.- ACTH(4 10) Analog Potentiates Cognitive and Morphological Recovery After Frontal Cortex Lesions in Adult Rats.- Effects of Neurotrophic Factors on the Secretion and Metabolism of the Alzheimer Amyloid Precursor.- Nerve Growth Factor Induces Differential Splicing of ?-Amyloid Precursor mRNAs in the PC12 Cell Line.- The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer s Disease Pathology.- The Neuritic Dystrophy of Alzheimer s Disease: Degeneration or Regeneration ?."Publisher Marketing: This volume contains the proceedings of the sixth Colloque M6decine et Re cherche organized by the Fondation Ipsen pour la Recherche Therapeutique and devoted to Alzheimer's disease. It was held in Strasbourg on April 25, 1990 and dedicated to growth factors and Alzheimer's disease. The proceedings of the previous meetings were published as the present one in the same series: Immunology and Alzheimer's disease (A. Pouplard-Barthelaix, J. Emile, Y Christen eds., 1988), Genetics and Alzheimer's disease (P.-M. Sinet, Y Lamour, Y Christen eds., 1988), Neuronal grafting and Alzheimer's disease (F. Gage, A. Privat, Y Christen eds., 1989), Biological markers and Alzheimer's disease (F. Boller, R. Katzman, A. Rascol, J.-L. Signoret, Y Christen eds., 1989), Imaging, cerebral topography and Alzheimer's disease (S. I. Rapoport, H. Petit, D. Leys, Y Christen eds., 1990). The next meeting of the series entitled Neurophilosophy and Alzheimer's disease was being held in La Jolla (California, USA) on January 11,1991. The proceed ings will be published this year. Yves Christen Fondation Ipsen Acknowledgements. The editors wish to express their gratitude to M. Sensenbren ner (Strasbourg), A. Bjorklund (Lund), R. Terry (La Jolla) for their collaboration as chairmen for the meeting, G. Vincendon, dean of the Facult6 de M6decine de Strasbourg, who made the introductive talk, Mary Lynn Gage for her editorial assistance and Jacqueline Mervaillie for the organization of the meeting. Contents Neurotrophic Factors and Neurodegenerative Diseases F Hefti and B. Knusel ............. ."

Contributor Bio:  Hefti, Franz Franz F. Hefti, PhD, held academic positions between 1985 and 1995, first as Associate Professor at the University of Miami, Florida, than as Professor with endowed chair at the University of Southern California in Los Angeles. He conducted pioneering research in the area of neurotrophic factors by demonstrating that these proteins can rescue dying nerve cells in the adult brain. He has served as Director of Neuroscience Research at Genentech Inc., pursuing industrial applications of his research on neurotrophic factors, leading to phase III trials with nerve growth factor. Since 1995 his activities have been dedicated to the discovery of novel drugs for neurological and psychiatric diseases in the pharmaceutical industry. From 1995 to 2001 he was Vice President at Merck Research Laboratories and Director of The Neuroscience Research Centre of Merck Sharp & Dohme. He later served as Senior Vice President of Neuroscience Research at Merck & Co.