Heinz Falk

Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, Vol. 92 - Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products Heinz Falk

Marc Notes: Includes bibliographical references and index. Table of Contents: List of Contributors -- Microbial Siderophores / Herbert Budzikiewicz -- 1. Introduction -- 2. Peptide Siderophores -- 2.1. Pyoverdins and Related Siderophores from Pseudomonas Spp -- 2.2. Azomonas and Azotobacter Siderophores -- 2.3. Anachelin -- 2.4. Actinomycetal Metabolites -- 2.5. Bacterial Hydroxamate Siderophores -- 2.6. Fungal L-Ornithine-Based Hydroxamate Siderophores -- 2.7. Catecholate Siderophores -- 2.8. Lipopeptidic Siderophores -- 2.9. Pseudomonas mendocina Siderophores -- 3. Siderophores Based on Diamino- and Triaminoalkane Skeletons -- 3.1. Rhizobactin -- 3.2. Catecholate Siderophores -- 3.3. Hydroxamic Acid Siderophores -- 4. Citrate Siderophores -- 4.1. Siderophores with Two Hydroxamic Acid Units -- 4.2. Siderophores with 2-Oxoglutaric Acid Units -- 4.3. Siderophores with Two Catecholate Units -- 4.4. Siderophores with Two Citric Acid Units -- 4.5. Legiobactin -- 5. Pyochelin and Related Structures -- 6. Miscellaneous Siderophores -- 7. Fe2+ Binding Ligands -- 8. Selected Syntheses -- 8.1. Anachelin H -- 8.2. Alterobactin -- 8.3. Parabactin -- 8.4. Nannochelin A -- 8.5. Pyochelin -- 9. Epilog -- Appendix -- Notes Added in Proof -- References -- Resin Glycosides from the Morning Glory Family / Rogelio Pereda-Miranda, Daniel Rosas-Ramirez, Jhon Castaneda-Gomez -- 1. Introduction -- 2. Ethnobotanical Background and Discovery -- 3. Structural Diversity -- 3.1. Chemical Composition -- 3.2. Resin Glycosides -- 4. Isolation Techniques -- 5. Structure Elucidation of Resin Glycosides -- 5.1. Degradative Chemical Methods -- 5.2. Spectroscopic Methods -- 5.3. Crystallographic Methods -- 5.4. Molecular Modeling -- 6. Strategies for Synthesis -- 6.1. Tricolorin A -- 6.2. Ipomoeassin E -- 6.3. Woodrosin I -- 7. Significance -- 7.1. Traditional Medicine and Morning Glories -- 7.2. Biological Activities -- 7.3. Pharmacology and Toxicology -- 7.4. Chemical Ecology -- References -- Author Index -- Subject Index. Publisher Marketing: Resin glycosides are part of a very extensive family of secondary metabolites known as glycolipids or lipo-oligosaccharides and are constituents of complex resins (glycoresins) (1) unique to the morning glory family, Convolvulaceae (2). These active principles are responsible for the drastic purgative action of all the important Convolvulaceous species used in traditional medicine throughout the world since ancient times. Several commercial purgative crude drugs can be prepared from the roots of different species of Mexican morning glories. Their incorporation as therapeutic agents in Europe is an outstanding example of the assimilation of botanical drugs from the Americas as substitutes for traditional Old World remedies (3). Even though phytochemical investigations on the constituents of these drugs were initiated during the second half of the nineteenth century, the structure of their active ingredients still remains poorly known for some examples of these purgative roots. During the last two decades, the higher resolution c- abilities of modern analytical isolation techniques used in conjunction with pow- ful spectroscopic methods have facilitated the elucidation of the active principles of these relevant herbal products. This chapter describes the ethnobotanical information associated with the p- gative morning glory species and how traditional usages were instrumental in plant selection for chemical studies. The advantages and limitations of available analy- cal techniques for the isolation, puri?cation, and structure characterization of the individual constituents of these complex glycoconjugates are also discussed.

Contributor Bio:  Falk, H Falk, Johannes-Kepler-Universitat, Linz, Austria.