Carlos a Guzm N

Pharmaceutical Biotechnology - Advances in Experimental Medicine and Biology Carlos a Guzm N 2009 edition

Marc Notes: Includes bibliographical references and index. Table of Contents: 1. Translational Medicine a Paradigm Shift in Modern Drug Discoveryand Development: The Role of Biomarkers Mark Day, J. Lynn Rutkowski and Giora Z. Feuerstein 2. Natural Products in Drug Discovery: Present Status and Perspectives Gabriella Molinari 3. Protein Pharmaceuticals: Discovery and Preclinical Development Davinder S. Gill 4. The Role of Nanobiotechnology in drug discovery Kewal K. Jain 5. Conotoxin Venom Peptide Therapeutics Richard J. Lewis 6. Shark novel antigen receptors the next generation of biologic therapeutics? Caroline Barelle, Davinder Gill and Keith Charlton 7. Immune Interventions of Human Diseases through Toll-Like Receptors Cevayir Coban, Ken J. Ishii and Shizuo Akira 8. Genome-Based Vaccine Development: A Short Cut for the Future Danilo Gomes Moriel, Maria Scarselli, Laura Serino, Marirosa Mora, Rino Rappuoli and Vega Masignani 9. The Antigenome: From Protein Subunit Vaccines to Antibody Treatments of Bacterial Infections? Carmen Giefing, Eszter Nagy and Alexander von Gabain 10. HSV as a vector in vaccine development and gene therapy Peggy Marconi, Rafaela Argnani, Alberto L. Epsteinand Roberto Manservigi 11. Virus-Like Particles as a Vaccine Delivery System: Myths and Facts Polly Roy and Rob Noad 12. Applications of Bacterial Ghosts in Biomedicine Petra Lubitz, Ulrike Beate Mayr and Werner Lubitz 13. Immune Modulators with Defined Molecular Targets: Cornerstone to Optimize Rational Vaccine Design Thomas Ebensen and Carlos A. Guzman 14. Innovative Approaches to Develop Prophylactic and Therapeutic Vaccines against HIV/AIDS Aurelio Cafaro, Iole Macchia, Maria Teresa Maggiorella, Fausto Titti and Barbara Ensoli 15. New Strategies to Overcome the Drawbacks of Currently Available Flu Vaccines Epifanio Fichera, Diana Felnerova, Robert Mischler, Jean-Francois Viret and ReinhardGlueck"Biographical Note: Carlos A. Guzman, MD, PhD is Head of the Department of Vaccinology and Applied Microbiology at the Helmholtz Centre for Infection Research (Braunschweig, Germany) and APL-Professor at the Medical School of Hannover. He is also German Coordinator for the International Doctorate in Experimental Oncology and Chair for Vaccines & Antiinfectives from the Indo-German Science Centre for Infectious Diseases. He graduated in Medicine at the National University of Rosario and obtained his Board Certification in Medical Bacteriology in Argentina. Then he moved to the Institute of Microbiology at the University of Genoa (Italy), as Research Fellow of the Italian Foreign Office Ministry. In Italy he also graduated as Doctor of Medicine and Surgery and obtained his Doctorate of Research in Microbiological Sciences. In 1994 he moved to Germany, where he became Head of the Vaccine Research Group at the German Research Centre for Biotechnology. He has been working in the field of vaccinology since 1989. His work has been instrumental for the development of new adjuvants, and the establishment of Salmonella spp. as a delivery system for DNA vaccines and therapeutic molecules. He has published more than 150 topic-related papers in international peer-reviewed journals and is co-inventor in several international patents. He is member of the Editorial Boards of Infection and Immunity, Microbial Biotechnology, Open Immunology Journal, Current Immunology Reviews, Open Vaccine Journal and Open Microbiology Journal, and Associate Editor of Human Vaccines. Giora Z. Feuerstein, MD, MSc, FAHA is Assistant Vice President and Head of Discovery Translational Medicine, Wyeth Research. Prior to joining Wyeth, Dr. Feuerstein has maintained Executive Directorship position in discovery of cardiovascular, stroke, thrombosis and metabolic disease programs for 16 years in SmithKline Beecham, DuPont Pharma and Merck USA. Dr. Feuerstein led the discovery program of Carvedilol (COR EG) for heart failure, eprosartan for hypertension and many development programs in stroke, anti-arrhythmics, thrombosis and metabolic diseases. Dr. Feuerstein serves as Editor, Biochemical Pharmacology, editorial boards of Journal of Pharmacology and Experimental Therapeutics, Journal of Cerebral Blood Flow Metabolism, Circulation Research, and Stroke. Dr. Feuerstein is the recipient of several national and international awards including Award of Excellent in Cardiovascular Research, AHA; Prix Galien Award for Drug Discovery (endothelin antagonist), Conrad R. Lam Award for cardiovascular research, Henry Ford Foundation and Wyeth R&D President award. Giora Feuerstein has authored and coauthored over 400 peer-reviewed publications and is co-inventor on 12 patents."Publisher Marketing: This book is a unique compilation of reviews addressing frontiers in biologicals from diverse perspectives, including basic research, biotechnology, protein delivery, pharmaceuticals and vaccinology. It covers a wide array of topics.