Adaptive Design Theory and Implementation Using SAS and R - Chapman & Hall / CRC Biostatistics Series - Mark Chang - Libros - Taylor & Francis Ltd - 9781138034235 - 14 de octubre de 2016
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Mark Chang
Adaptive Design Theory and Implementation Using SAS and R - Chapman & Hall / CRC Biostatistics Series 2.º edición

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Get Up to Speed on Many Types of Adaptive Designs

Since the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the use of various adaptive design methods in clinical trials.

New to the Second Edition

  • Twelve new chapters covering blinded and semi-blinded sample size reestimation design, pick-the-winners design, biomarker-informed adaptive design, Bayesian designs, adaptive multiregional trial design, SAS and R for group sequential design, and much more
  • More analytical methods for K-stage adaptive designs, multiple-endpoint adaptive design, survival modeling, and adaptive treatment switching
  • New material on sequential parallel designs with rerandomization and the skeleton approach in adaptive dose-escalation trials
  • Twenty new SAS macros and R functions
  • Enhanced end-of-chapter problems that give readers hands-on practice addressing issues encountered in designing real-life adaptive trials

Covering even more adaptive designs, this book provides biostatisticians, clinical scientists, and regulatory reviewers with up-to-date details on this innovative area in pharmaceutical research and development. Practitioners will be able to improve the efficiency of their trial design, thereby reducing the time and cost of drug development.

706 pages, 42 black & white illustrations, 113 black & white tables

Medios de comunicación Libros     Paperback Book   (Libro con tapa blanda y lomo encolado)
Publicado 14 de octubre de 2016
ISBN13 9781138034235
Editores Taylor & Francis Ltd
Páginas 706
Dimensiones 238 × 159 × 43 mm   ·   1,06 kg
Lengua Inglés  

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